Importance of Gene-Gene Interactions Shown in Study

更多地洞察预测基因通过绘制基因型 - 表型图来影响基因的基因或行为性状，该型在个性化药物中具有速度发现。但是，究竟究竟是如何互动的根本依据地图的左侧部分。

在发表的论文中国家科学院的诉讼程序, North Carolina State University genetics researchers reveal some of the hidden portions of the map, showing that complicated networks of gene-gene interactions in fruit flies greatly influence the variance in quantitative traits, or characteristics that are influenced by multiple genes – like sensitivity to alcohol or aggression.

The effects of these gene-gene interactions, known as epistatic effects, are difficult to gauge in human populations because some variations are unknown, says Dr. Trudy Mackay, William Neal Reynolds and Distinguished University Professor of Genetics at NC State and the paper’s corresponding author.

“One of the ways we model the genotype-phenotype map in humans – one variant at a time – may be wrong,” Mackay says. “Over the past four or five years, thousands of genomewide studies have focused on how variants affect traits, but the effects shown have been really small.

“这就像大象和劳保局的比喻nd men, in which one blind man feels the elephant’s trunk and believes he’s touching a snake, while another man touches the elephant’s knee and believes he’s touching a tree. Using just one interaction doesn’t help the men identify the elephant.”

进入Mackay和她的水果苍蝇 - 近200行的遗传相同的苍蝇，也是不同特征的遗传变异样本，以及数千只杂交以随着基因随后改变基因的苍蝇。

In three studied traits, the PNAS paper compared identical flies with crossbred “mutt” flies and, surprisingly, showed no matched variations in chemical building blocks known as single-nucleotide polymorphisms.

然而，本文表明，该背景网络可用于预测三个研究的特征的变化。

Mackay表示本文中获得的知识可用于寻找人类基因组协会研究中的认识性相互作用。

“Understanding how genetic variation in an individual gives rise to susceptibility to complex diseases like diabetes or schizophrenia – or even to traits like height – is one of the open questions in quantitative genetics today, ” Mackay says. “Knowing a person’s particular variants could motivate therapeutic treatments.”

The study was funded by the National Institutes of Health and the National Human Genome Research Institute. Colleagues from the Baylor College of Medicine collaborated on the research.

- Kulikowski -

编辑的注释：纸上的摘要跟随。

Epostasis主导了果蝇定量特征的遗传建筑

作者：Trudy F.C.Mackay，Wen Huang，Mary Anna Carbone，Robert R.H. Anholt，Julie F. Ayroles，Laura Duncan，Katherine W.Jordan，Faye Lawrence，Michael M. Magwire，Eric A. Stone，北卡罗来纳州立大学;斯蒂芬理查兹，天化朱，水晶贝德堡，易汉，梅霍维什·爪哇省，乔塞琳·哈曼，唐娜·穆斯尼亚，唐娜·穆斯尼亚，袁青吴，义庆张，萧文邹，理查德·吉布斯，贝勒学院药物

发表: Online the week of Sept. 3, 2012 in国家科学院的诉讼程序

抽象的：超越 - 多晶型基因座之间的非线性遗传相互作用 - 是释放和形态的遗传基础，并且可以使用远古相互作用来推断出影响定量性状的遗传网络。然而，在定量特征的遗传架构中发挥的作用超越争议是有争议的。在这里，我们将三种果蝇的遗传建筑与果蝇遗传基团（DGRP）的测序血交线中的三种果蝇生命历史特征进行了比较，并在衍生自40 DGRP线条（“香槟”）的大郊区和大型轰炸中的癌症。通过深DNA测序，我们评估了在香槟种群中每个特征的极端分布的个人之间的等位基因频率变化。两种分析中，所有特征的遗传架构都是高度多的。令人惊讶的是，与在DGRP中复制的香槟色的特征相关的单一核苷酸多态性（SNP）都不是，反之亦然。然而，大多数这些SNP参与了DGRP中的至少一个认证互动。尽管两种群体中具有明显不同的基因座的表观添加剂效应，但是本质交互扰动常见，生物合理性和高度连接的遗传网络。我们的分析强调了外观作为确定定量性状变化的主要因素，并提供了揭示影响这些特征的新型遗传网络的方法。背景技术的知识将有助于我们对进化遗传学和临床重要特征的遗传基础的理解，提高医学和农业中个性化水平的预测能力。