Researchers Craft Tool to Minimize Threat of Endocrine Disruptors in New Chemicals

Researchers from North Carolina State University, the National Institute of Environmental Health Sciences and a host of other institutions have developed a safety testing system to help chemists design inherently safer chemicals and processes.

创新的“得到”测试系统tem (Tiered Protocol for Endocrine Disruption) stems from a cross-disciplinary collaboration among scientists, and can be applied at different phases of the chemical design process. The goal of the system is to help steer companies away from inadvertently creating harmful products, and thus avoid adding another BPA or DDT to the marketplace.

A paper describing the work, “Designing Endocrine Disruption Out of the Next Generation of Chemicals，“在线在线在线化学学报绿色化学。

“In order to reduce our exposure to endocrine disruptors, we have to ensure that new products entering the market do not contain them,” says Dr. Heather Patisaul, an associate professor of biology at NC State and co-author of the paper. “The goal of this project is to develop an effective strategy for chemists, engineers, and manufacturers to identify potential endocrine disruptors before they are used in commercial products. Identifying these types of chemicals early in the design process will ultimately help ensure that we develop the safest products possible, which benefits consumers.”

The work was conducted by biologists, green chemists and others from North America and Europe who say that recent product recalls and bans reveal that neither product manufacturers nor governments have adequate tools for dealing with endocrine disrupting chemicals (EDCs). EDCs are chemicals commonly used in consumer products that can mimic hormones and lead to a host of modern-day health epidemics including cancers, learning disabilities and immune system disorders.

The authors conclude that as our understanding of the threat to human health grows, the need for an effective testing strategy for endocrine disrupting chemicals becomes imperative.

Historically, chemists have aimed to make products that are effective and economical. Considering toxicity when designing new chemicals has not been their responsibility. This collaboration between fields expands the scope of both biologists and chemists to lead to a way to design safer chemicals.

纸上有一个伴侣网站，www.TiPEDinfo.com. One can access the paper there and learn more about the TiPED system.

本文由NC州，加州大学，加州大学，Carnegie Mellon University，德克萨斯大学，弗吉尼亚联邦大学德克萨斯大学，弗吉尼亚州奥斯汀大学，推进路易斯安那州高校，路易斯安那州德克萨斯大学，加州大学南卡罗来纳医科大学，伯克利大学，俄勒冈州立大学，塔夫斯大学，德克萨斯大学Missachusts大学德克萨斯大学的华纳Babcock绿色化学研究所 -阿默斯特和环境健康科学。

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Note to Editors:The study abstract follows.

“在下一代化学品中设计内分泌干扰”

Authors: T. T. Schug, R. Abagyan, B. Blumberg, T. J. Collins, D. Crews, P. L. DeFur, S. M. Dickerson, T. M. Edwards, A. C. Gore, L. J. Guillette, T. Hayes, J. J. Heindel, A. Moore , H. B. Patisaul, T. L. Tal, K. A. Thayer, L. N. Vandenberg, J. C. Warner, C. S. Watson, F. S. vom Saal, R. T. Zoeller, K. P. O’Brien and J. P. Myers.

Published: Dec. 6,Green Chemistry

Abstract:绿色化学的核心目标是避免在新化学品设计中的危害。当在设计过程中尽早获得有关化学潜在危险效果的信息时，最佳实现该目的是最好的。内分泌破坏是一种迄今为止迄今为止的危险，由工业和监管科学都不足以解决。为了援助化学家避免这种危害，我们提出了一种内分泌破坏测试方案，用于化学家在设计新化学品的设计中。在一个由绿色化学和环境卫生科学的领导代表组成的科学咨询委员会的监督下，制定了内分泌干扰（提示）的分层议定书。提示被认为是新化学设计的工具，因此它从理论上以“绘图板”理论上以化学家开头。它由五种测试层组成，通过特异性细胞和全部有机体的测定来从硅评估广泛。为了有效地检测内分泌破坏，测试方案必须能够测量化学物质的潜在激素或激素抑制效果，以及这种化学品的许多可能的相互作用和信号螯合物可能具有基于细胞的受体。因此，我们设计了本协议以广泛地询问内分泌系统。该拟议的议定书将不会检测到内分泌干扰的所有可能机制，因为对这些现象的科学了解正在迅速推进。 To ensure that the protocol remains current, we have established a plan for incorporating new assays into the protocol as the science advances. In this paper we present the principles that should guide the science of testing new chemicals for endocrine disruption, as well as principles by which to evaluate individual assays for applicability, and laboratories for reliability. In a ‘proof-of-principle’ test, we ran 6 endocrine disrupting chemicals (EDCs) that act via different endocrinological mechanisms through the protocol using published literature. Each was identified as endocrine active by one or more tiers. We believe that this voluntary testing protocol will be a dynamic tool to facilitate efficient and early identification of potentially problematic chemicals, while ultimately reducing the risks to public health.