“三活性”避孕凝胶结合了精子，抗病毒，性欲增强剂

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特蕾西·皮克（Tracey Peake） tracey_peake@ncsu.edu

来自北卡罗来纳州立大学的研究人员创建了一种三官能避孕凝胶，其中包含一种配方中的精子，抗病毒和性欲增强剂。当在大鼠模型中进行测试时，凝胶均增强了男性性欲，并在100％的病例中预防了怀孕，相比之下，使用市售避孕凝胶的平均有效率为87％。

“We are using three pharmacological agents in a new formulation,” says Ke Cheng, Randall B. Terry, Jr. Distinguished Professor in Regenerative Medicine at NC State’s College of Veterinary Medicine, professor in the NC State/UNC Joint Department of Biomedical Engineering and corresponding author of a paper describing the work. “Our hope is that this trifunctional contraceptive gel could further enhance the safety and quality of sexual intercourse.”

The new carbomer-based gel contains the contraceptive gossypol, the antiviral tenofovir and nitroglycerin to stimulate blood flow.

Cheng and his team first tested the gel in vitro to determine spermicidal and antiviral efficacy, as well as toxicity to vaginal epithelial cells. At 10 micrograms per milliliter gossypol concentration, the gel was effective in killing almost 100% of pig sperm – used for in vitro testing – in 30 seconds. Lower concentrations were equally effective by 180 seconds.

他们还在体外测试了凝胶针对慢病毒的凝胶，发现它确实具有抑制作用，这表明其可能减少性传播疾病的传播潜力。凝胶还显示出对上皮阴道细胞的破坏，因为处理细胞中的细胞损伤与未处理或对照细胞没有显着差异。

Next, the researchers looked at contraceptive effects in a rat model. Eighteen female rats were divided into three groups: one that received the new gel; one that received a common commercially available contraceptive gel containing nonoxynol9; and a control. The females in the trifunctional gel group had no pregnancies, as opposed to one pregnancy in the nonoxynol9 group.

该小组还测试了凝胶对雄性老鼠的性欲和勃起功能的影响。接收凝胶的大鼠比没有凝胶的大鼠更频繁地与孵化时间较短。

Cheng说：“我们创建的三功能避孕凝胶比市场上的避孕成功率更高。”

The research appears in生物活性材料。

-Ceake-

注释编辑：An abstract follows.

“三官能避孕凝胶可以增强性交的安全性和质量”

doi：10.1016/j.bioactmat.2020.11.031

作者：Mengjie Xie, Junlang Li, Sichen Zhang, Dashuai Zhu, Xuan Mei, Zhenzhen Wang, Xiao Cheng, Zhenhua Li, Ke Cheng, North Carolina State University; Shaowei Wang, Chinese Academy of Medical Sciences
出版：Online Dec. 3, 2020 in生物活性材料

抽象的：
在商业避孕凝胶的情况下，当前的避孕方法具有许多缺点，包括低疗法，以及在避孕套的情况下降低了性交的质量。添加药理学活性剂来避孕凝胶具有改善性经历以及硬伯爵安全和卫生的潜力。在这项研究中，我们制造了一种基于Carbomer的避孕凝胶，该避孕凝胶由三种剂：替诺福韦，乙酸苔藓酸酯和硝酸甘油（TGN），pH调节至4.5（与阴道兼容）。在体外，事实证明，避孕凝胶的棉醇成分是有效的杀精子剂。当乙酸棉能的浓度为10 mg/mL时，杀精性能力在30 s后达到100％。此外，凝胶中的Tenofovir显着抑制含细胞培养基的慢病毒转染效率。在6对大鼠中，凝胶成功地阻止了所有女性成功交配后。此外，在成分中硝酸甘油促进的性频率和增强的勃起，在将凝胶应用于其阴茎的雄性大鼠中观察到。与商业避孕凝胶相比，这种新型TGN避孕凝胶的避孕成功率（Contagel®）具有更高的避孕成功率。此外，在性交期间，它具有额外的好处，可预防性传播疾病并改善男性性欲和勃起功能。 Combining three FDA-approved and marketed agents together, our trifunctional TGN gel has a great potential for further translation and commercialization.